This guide was developed by the Mali Ministry of Health (MOH) to strengthen the constructive participation of men in reproductive health (RH) as a strategy to improve the health of the population. It is intended for RH service providers, the staff of non-governmental organizations, and technical partners of the Mali MOH. It includes guidelines and strategies for each of the following program domains: improvement of RH services for men; raising awareness and community mobilization; behavior-change communication to promote men’s participation in RH (as members of couples and as community members); strengthening the capacity of program managers and health professionals to constructively engage men in RH services; advocacy for political and institutional support for constructive men’s engagement; and research, monitoring, and evaluation of CME-RH programs.